| 1512 | Quli Qutub Shah established Qutub Shahi dynasty by seizing reins of power from Bahamanis. Established fortress city of Golconda. |
| 1562 | Hussain Sagar lake was built. |
| 1589 | Hyderabad was founded by Muhammad Quli Qutub Shah. |
| 1591 | Charminar was built |
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| 1614 | Work on Mecca Masjid started |
| 1687 | Building of Mecca Masjid completed Aurangzeb captured Golconda. |
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| 1724 | Nizam-ul-Mulk Asif Jah I founded Asif Jahi Dynasty by declaring Independence from Mughal Rulers. |
| 1748 | Death of Asif Jah( Nizam-Ul-Mulk - Nizam I) at the age of 78. |
| 1766 | Nizam made an alliance with the British. |
| 1769 | Nizam Ali Khan Asif Jah shifted the capital to Hyderabad. |
| 1777 | Purani haveli constructed by Mir Nizam Ali Khan , the second Nizam
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| 1798 | Subsidiary alliance for military and political co-operation signed between the Nizam and the British East India Company. Nizam relinquished control of the state's foreign affaires to British. |
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| 1803 | Death of Nizam II - Nizam Ali Khan at the age of 72. |
| 1804 | Construction of Mir Alam Tank began and completed in 1806 |
| 1806 | Secunderabad founded |
| 1829 | Death of Nizam III - Sikander Jah at the age of 62 |
| 1857 | Death of Nizam IV - Nasir-Ud-Dowla |
| 1858 | A new coinage "Hali Sicca" introduced with inscription 'Sicca-e- Nizamul-Mulk Asif Jah Bhadur' |
| 1864 | Hyderabad Medical School established |
| 1866 | Birth of Nizam VI - Mahboob Ali Khan |
| 1867 | Government Central Printing Press was established |
| 1867 | Mir Osman Ali Khan , the last Nizam died on 24 Feb 1967 |
| 1868 | Basir Bagh Palace was constructed by Sir Asam Jah |
| 1884 | Foundation of Falaknuma Palace Official language was changed from Persian to Urdu Director General of Police and Jail Department were established |
| 1887 | Sir Ronald Ross discovered the Parasite of Malaria |
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| 1908 | Disastrous floods in River Musi |
| 1911 | Death of Nizam VI- mahaboob Ali Khan at the age of 45. |
| 1915 | Construction of High Court began and completed in 1919 |
| 1931 | Osmania University building Project started |
| 1948 | Hyderabad merged into the Indian Union |
| 1956 | Hyderabad became capital of Andhra Pradesh |
| 1976 | Birla Temple constructed |
| 1986 | Death of Nizam V - Afzal-Ud-Dowla at the age of forty three years |
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| 1998 | Hi-tech City inaugurated |